In a world facing a range of health threats, from viral outbreaks to drug-resistant bacteria, the demand for quick, reliable, and easy-to-use home diagnostic tests has never been more urgent. Imagine a future where these tests can be performed anywhere, by anyone, using a device as compact and portable as a smartwatch. Achieving this requires microchips capable of detecting even the smallest concentrations of viruses or bacteria in the air.

New research from NYU Tandon, led by Professor Davood Shahrjerdi, Professor Elisa Riedo, and Giuseppe de Peppo, demonstrates that it is possible to develop microchips capable of detecting multiple diseases from a single cough or air sample, and that these chips can be produced at scale.

"This study opens new horizons in the field of biosensing," said Riedo. "Microchips, which are the backbone of smartphones and computers, have transformed the way people communicate and work. Similarly, our technology will revolutionize healthcare, from diagnostics to environmental health."

The technology uses field-effect transistors (FETs)—miniature electronic sensors that directly detect biological markers and convert them into digital signals. These sensors offer an alternative to traditional color-based diagnostic tests like home pregnancy tests. According to Shahrjerdi, this technology provides faster results, the ability to test for multiple diseases at once, and immediate data transmission to healthcare providers.

FETs are already central to modern electronics, and their adaptation as biosensors marks a significant step forward in diagnostics. These tiny devices can detect specific pathogens or biomarkers in real-time, without needing chemical labels or complex lab procedures. By converting biological interactions into measurable electrical signals, FET-based biosensors provide a rapid and versatile diagnostic platform.

https://github.com/GavinARP/King-Arthur-Legends-Rise-MOD-unlimited-money-and-gems

https://github.com/ChrisGNTT/Cooking-World-Restaurant-Game-MOD-unlimited-everything

https://github.com/StevenAAT/Eden-Fantasia-Idle-Goddess-MOD-unlimited-diamonds-and-summon-scrolls

https://github.com/RonaldSBT/Isekai-Saga-Awake-MOD-unlimited-gold

https://github.com/OliverMNT/Backpacker-Go-MOD-unlimited-dice-rolls

https://github.com/AdamBNH/Supreme-Duelist-Stickman-MOD-unlimited-money-and-max-level

https://github.com/AndrewTNV/Moba-Legends-5v5-MOD-unlimited-diamonds

https://github.com/BlakeAGT/Ultimate-Traffic-Driving-Car-MOD-unlimited-money-and-gems

https://github.com/BradleyTMN/Squad-Busters-MOD-unlimited-money-and-gems

https://github.com/ChristianBNT/BitLife-MOD-unlimited-money-and-bitizenship

https://github.com/ColinBMG/Top-Heroes-MOD-unlimited-money-and-diamonds

https://github.com/CraigDTS/GIRLS-FRONTLINE-2-EXILIUM-MOD-unlimited-gems

https://github.com/DominicGNE/Blood-Strike-unlimited-money-and-gold

https://github.com/EvanDNT/Animals-and-Coins-MOD-unlimited-energy

https://github.com/GeorgeMNB/Tower-War-MOD-unlimited-money-and-gems

https://github.com/JacobHNT/Cooking-Madness-MOD-unlimited-money-and-gems

https://github.com/JohnGNT/Pirate-King-Legend-MOD-unlimited-gems

https://github.com/LanceDVN/Mech-Arena-MOD-unlimited-A-coins-and-credits

https://github.com/MasonBLT/Age-of-Origins-MOD-unlimited-everything

Recent advancements have enhanced the sensitivity of FET biosensors to femtomolar concentrations (one quadrillionth of a mole) using materials like nanowires, indium oxide, and graphene. However, the challenge remains: current methods lack the precision needed to detect multiple pathogens on a single chip. Researchers are now exploring ways to modify FET surfaces to enable each transistor on a chip to detect a different biomarker, allowing for the simultaneous detection of multiple pathogens.

This is where thermal scanning probe lithography (tSPL) comes in. This breakthrough technology allows precise chemical patterning on polymer-coated chips, enabling individual FETs to be functionalized with different bioreceptors, such as antibodies, at resolutions as fine as 20 nanometers. This process, which is comparable to the size of modern semiconductor transistors, offers a way to create FET-based sensors that can detect a wide variety of pathogens on a single chip with exceptional sensitivity.

Riedo, who played a key role in the development of tSPL technology, sees its potential as proof of the groundbreaking applications this nanofabrication technique can offer. "tSPL has been critical in allowing us to functionalize each FET with different bioreceptors to achieve multiplexing," she says.