Reducing Minion Resistances
Despair (Curse for Chaos Damage): If your build uses chaos damage, Despair is an incredibly powerful curse to Path of exile currency use. It reduces the chaos resistance of enemies, which will increase the effectiveness of your chaos-based attacks against minions.
Flammability (Curse for Fire Damage): For fire builds, Flammability reduces the fire resistance of minions, allowing you to deal much more damage. Since fire damage typically has strong AoE effects, this curse will amplify your ability to clear groups of minions quickly.
Frostbite (Curse for Cold Damage): Frostbite reduces cold resistance, making it ideal for cold builds. It will help your cold AoE attacks (like Vortex or Fireball) become even more lethal against large groups of adds.
Increasing Minion Vulnerability
Elemental Weakness: For builds that deal elemental damage (fire, cold, or lightning), Elemental Weakness is a potent debuff that reduces the elemental resistances of minions. This makes them more susceptible to your damage and is especially useful when clearing diverse minion types that may have higher resistances.
Vulnerability: This curse increases the physical damage taken by enemies. It's great for physical-based builds or any character dealing melee damage. If you are fighting tankier minions, this curse can help tear through their high health pools.
Additional Control Debuffs
Elemental and Physical Exposure: If you are using elemental or physical damage, Exposure effects (via Elemental Exposure or Physical Exposure) can drastically reduce the resistances of minions. These debuffs make minions far more vulnerable to your attacks, helping you melt through them faster.
Punishment: Punishment is a curse that increases the damage taken by enemies when they’re at high life. This is especially effective against tankier minions or Path of exile currency for sale enemies that have high health. The more health they have, the more damage they’ll take from your attacks when Punishment is active.